姓名 | 张阳 |
2021级 | 博士后 |
感兴趣的方向 |
功能蛋白及小分子药物纳米化
|
2015年至2021年在厦门大学公共卫生学院学习并获得理学博士学位，导师刘刚教授。研究兴趣是功能蛋白及小分子药物纳米化的探究及其生物医学应用，在功能蛋白基因改造及超均相纯药复合制剂研发方面具有扎实的理论实践基础。迄今以第一作者/通讯作者身份（含共同）在Nature Communications、Nano Today、ACS Nano、Biomaterials等国际知名学术期刊发表论文13篇；共同作者身份在Science Advances、Angewandte Chemie、Advanced Materials等知名学术期刊发表论文20余篇；被引次数超过1200，申请专利7项，其中授权5项，企业转化3项。作为技术骨干研发的肝癌靶向性药物在华西医院、西南医院、厦门大学附属中山医院等11家三甲医院开展30余例临床试验（持续推进中）。曾获得研究生国家奖学金、厦门大学“本栋奖学金”、“茅台奖学金”等各类奖学金20余次，并获中国博士后基金第70批面上基金、厦门大学生命科学与人类健康学科群优秀博士后项目等资助。
教育背景：
2021.07-至今：厦门大学，博士后，化学，合作导师刘刚教授（国家杰青）
2015.09-2021.06：厦门大学，生物化学与分子生物学专业，获理学博士学位，导师刘刚教授（国家杰青）
2011.09-2015.06：重庆大学，生物工程专业，获工学学士学位
已发表论文：
1. Yang Zhang, Xiaoyong Wang, Chengchao Chu, Zijian Zhou, Biaoqi Chen, Xin Pang, Gan Lin, Huirong Lin, Yuxin Guo, En Ren, Peng Lv, Yesi Shi, Qingbing Zheng, Xiaohui Yan, Xiaoyuan Chen, and Gang Liu*. Genetically Engineered Magnetic Nanocages for Cancer Magneto-Catalytic Theranostics. Nature Communications. 2020, 11, 5421. （IF: 14.919）
2. Yang Zhang#, Hongwei Cheng#, Hu Chen#, Peiyao Xu #, En Ren, Yonghe Jiang, Dengfeng Li , Xing Gao , Yating Zheng , Pan He , Huirong Lin, Biaoqi Chen, Gan Lin, Aizheng Chen, Chengchao Chu *, Jingsong Mao*, Gang Liu*. A pure nanoICG-based homogeneous lipiodol formulation: Toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. European Journal of Nuclear Medicine and Molecular Imaging. 2021,DOI: 10.1007/s00259-021-05654-z （IF: 9.236）
3. Pan He#, En Ren#, Biaoqi Chen#, Hu Chen#, Hongwei Cheng, Xing Gao, Xiaoliu Liang, Hao Liu, Jingdong Li, Bo Li, Aizheng Chen, Chengchao Chu, Jingsong Mao,*, Yang Zhang *, Gang Liu*. A super-stable homogeneous lipiodol-hydrophilic chemodrug formulation for treatment of hepatocellular carcinoma. Theranostics. 2022，12(4)：1769-1782. （IF: 11.556）
4. Shuang Bai#, Zhixiang Lu#, Yonghe Jiang, Xiaoxiao Shi, Dazhuang Xu, Yesi Shi, Gan Lin, Chao Liu, Yang Zhang*, Gang Liu*. Nanotransferrin-based programmable catalysis mediates three-pronged induction of oxidative stress to enhance cancer immunotherapy. ACS NANO. 2022, 16(1)：997-1012. （IF: 15.881）
5. Xiaoxiao Shi#, Yang Zhang#, Shuyu Xu#, Shuang Bai, Xue Liu, Yonghe Jiang, Chao Liu* , Gang Liu*. Unimolecule-based Size-charge Switchable Nanomedicine for Deep Cancer Sono-immunotherapy. Nano Today. 2022, 43: 101417 （IF: 20.722）
6. Shuang Li#, Yang Zhang#, Xue Liu, Ye Tian, Yi Cheng, Longguang Tang*, Huirong Lin*. Smart NIR-II croconaine dye-peptide for enhanced photo-sonotheranostics of hepatocellular carcinoma. Theranostics. 2020, 12 (1): 76-86. （IF:11.556）
7. Gan Lin#, Yang Zhang#, Congqing Zhu, Chengchao Chu, Yesi Shi, Xin Pang, En Ren, Yayun Wu, Peng Mi, Haiping Xia, Xiaoyuan Chen, and Gang Liu*. Photo-excitable Hybrid Nanocomposites for Image-guided Photo/TRAIL Synergistic Cancer Therapy. Biomaterials. 2018, 176:60-70. （IF: 12.479）
8. Xiaoxiao Shi#, Yang Zhang#, Ye Tian#, Shuyu Xu, En Ren, Shuang Bai, Xiaoyuan Chen, Chengchao Chu*, Zhigang Xu*, and Gang Liu*. Multi-responsive Bottlebrush-Like Unimolecules Self-Assembled Nano-Riceball for Synergistic Sono-Chemotherapy. Small Methods. 2020, 2000416. （IF: 14.188）
9. Shuang Bai#, Yang Zhang#, Dengfeng Li, Xiaoxiao Shi，Gan Lin, and Gang Liu*. Gain an advantage from both sides: Smart size-shrinkable drug delivery nanosystems for high accumulation and deep penetration. Nano Today. 2020, 101038. （IF: 20.722）
10. Gan Lin#, Yang Zhang#, Long Zhang#, Junqing Wang, Ye Tian, Wen Cai, Shangui Tang, Chengchao Chu, JiaJing Zhou, Peng Mi, Xiaoyuan Chen, and Gang Liu*. Metal-organic frameworks nanoswitch: Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference. Nano Research. 2020, 13(1):238-245. （IF: 8.897）
11. Wen Cai*#, Yang Zhang#, Junqing Wang, Zhiyong Wang, Ye Tian, Heng Liu, Hongzhi Pan, Li Fu, Chengchao Chu, Wei Chen, Chusheng Wu, Xiaoyong Wang, and Gang Liu*. Surface Functionalized Gd2O3 Nanoplates for T1-weighted Magnetic Resonance Imaging. Chemical Engineering Journal, 2020, 380:122473. （IF: 13.273）
12. Xiaojie Zhang#, Yang Zhang#, Yunming Zhang#, Peng Lv, Pengfei Zhang, Chengchao Chu, Jingsong Mao, Xiaoyong Wang*, Wengang Li*, and Gang Liu*. Bio-engineered Cell Membrane Nanovesicles as Precision Theranostics for Perihilar Cholangiocarcinoma. Biomaterials Science, 2020, 8:1575-1579. （IF: 6.843）
13. Yonghe Jiang#, Yang Zhang#, Zhixiang Lu#, Xiaoyong Wang, Shuang Bai, Yulun Chen, Jingsong Mao*, Gang Liu*. Liquid Embolic Agents for Interventional Embolization. ChemPhyMater. 2022,1(1):39-50.
