SYED FAHEEM ASKARI RIZVI
E-mail：
sfarizvi@xmu.edu.cn
Correspondence Address:
School of Public Health, Xiang'an Campus of Xiamen University, Xiamen, Fujian, China
Research Direction:
Dedicated to peptide chemistry and radiopharmaceuticals, mainly engaged in the design, synthesis and related functional research of new peptide drugs, small molecular linkers/ chelators, self-assembly of peptide drugs, and construction of peptide-drug conjugates. The research content mainly includes:
1. Synthesis of novel small cyclic peptide analogs suitable as drug candidate and/or carrier agent of fluorescent probes, radionuclides, and chemotherapeutics
2. Construction of peptide-drug conjugates for efficient delivery of poor water soluble drugs as well as targeted delivery and biological applications (in vitro and in vivo) of bioconjugates
3. Synthesis of novel small molecular linkers/chelators as a bridging moiety for peptides, chemotherapeutics, radionuclides
Education and work experience:
2024.10 – present ICGEB-IFP (Research Associate), School of Public Health, Xiamen University, China, Co-supervisor: Professor Liu Gang
2022.07 – 2024.05 Postdoctoral Fellow, School of Basic Medicine, Lanzhou University, China, Co-supervisor: Professor Quan Fang
2021.03 – 2024.07 Assistant Professor, Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan
2018.09 – 2021.12 Ph.D. Chemistry, School of Chemistry and Chemical Engineering, Lanzhou University, China, Ph.D. supervisor: Professor Haixia Zhang
2015.10 – 2018.08 Research Associate, Institute of Chemistry, Government College University, Faisalabad, Pakistan
2013.08 – 2015.10 Lecturer & Head of Department Chemistry, Punjab Group of Colleges, Pakistan
2010.09 – 2012.11 Master of Philosophy in Chemistry, Institute of Chemistry, Government College University, Faisalabad, Pakistan, Master supervisor: Professor Tanveer Hussain Bokhari
2006.09 – 2010.07 Bachelor of Science, Institute of Chemistry, University of Sargodha, Pakistan
Published papers: (* corresponding authors)
1. Syed Faheem Askari Rizvi*, Haixia Zhang*, Quan Fang. Engineering Peptide Drug Therapeutics through Chemical Conjugation and Implications in Clinics. Medicinal Research Review, 05.05.2024, 10.1002/med.22046. (Impact Factor 13.3)
2. Syed Faheem Askari Rizvi, Linjie Zhang, Haixia Zhang*, Quan Fang*. Peptide-Drug Conjugates: Design, Chemistry, and Drug Delivery System as a Novel Cancer Theranostic, ACS Pharmacology & Translational Science, 24.01.2024, 7, 2, 309-334, 10.1021/acsptsci.3c00269. (Impact Factor 6.0)
3. Syed Faheem Askari Rizvi*, Nadir Abbas, Haixia Zhang, Quan Fang. Identification of a pH-Responsive Peptide-Paclitaxel Conjugate as a Novel Drug with Improved Therapeutic Potential. ACS J. Med. Chem., 07.06.2023, 66, 12, 8324-8337, 10.1021/acs.jmedchem.3c00382. (Impact Factor 8.039)
4. Syed Faheem Askari Rizvi, Munir Ahmad, Farzana Muneeb, Haixia Zhang*. Preclinical assessment of Alzheimer's disease using novel designed 99mTc-labeled RGD-based pro-apoptotic cyclic peptide as a promising SPECT agent. Applied Organometallic Chemistry, 02.01.2022, 36 (03) e6569-6572. DOI: 10.1002/aoc.6569. (Impact Factor 4.105)
5. Syed Faheem Askari Rizvi, Mu Shuai, Samiah Shahid, Chunyan Zhao, Haixia Zhang*. Fabrication of self-assembled peptide nanoparticles for in vitro assessment of cell apoptosis pathway and in vivo therapeutic efficacy. Microchimica Acta, 08 Jan 2022, 189, 1-14. DOI: 10.1007/s00604-021-05148-7. (Impact Factor 6.408)
6. Syed Faheem Askari Rizvi*, Azam Ali, Munir Ahmad, Shuai Mu, Haixia Zhang*. Multifunctional Self-assembled peptide nanoparticles for multimodal imaging-guided enhanced theranostic applications against glioblastoma multiforme. RSC Nanoscale Advances, 15.09.2021, 3 (20), 5959-5967. DOI; 10.1039/D1NA00597A (Impact Factor 5.598)
7. Syed Faheem Askari Rizvi, Samiah Shahid, Shuai Mu, Haixia Zhang*. Hybridization of tumor homing and mitochondria‑targeting peptide domains to design novel dual‑imaging self‑assembled peptide nanoparticles for theranostic applications. Drug Delivery and Translational Research, 17.09.2021, 12, 1774-1785. DOI: 10.1007/s13346-021-01066-6. (Impact Factor 5.671)
8. Syed Faheem Askari Rizvi and Haixia Zhang*. Emerging trends of receptor-mediated tumor targeting peptides: A review with perspective from molecular imaging modalities. European Journal of Medicinal Chemistry, 05.10.2021, 221, 113538. DOI: 10.1016/j.ejmech.2021.113538 (Impact Factor 7.088)
9. Syed Faheem Askari Rizvi, Haixia Zhang*, Sajid Mehmood, Mahmoud Sanad. Synthesis of 99mTc-labeled 2-Mercaptobenzimidazole as a novel radiotracer to diagnose tumor hypoxia. Translational Oncology, 28.08.2020, 13 (12), 100854. DOI: 10.1016/j.tranon.2020.100854 (Impact Factor 4.803)
10. Syed Faheem Askari Rizvi, Shuai Mu, Yaya Wang, Shuangqin Liu, Haixia Zhang*. Fluorescent RGD-based pro-apoptotic peptide conjugates as mitochondria-targeting probes for enhanced anticancer activities. Biomedicine and Pharmacotherapy. 05.05.2020, 127, 110179. DOI: 10.1016/j.biopha.2020.110179 (Impact Factor 6.529)
11. Fatima Khalid, Reema Tahir, Manahil Ellahi, Nilofer Amir, Ammarah Hasnain, Syed Faheem Askari Rizvi*. Emerging Trend of Edible Vaccine as a Versatile Platform for Combating Human Diseases Including COVID-19: Pros, Cons and Future Perspectives. Phytotherapy Research, 02.05.2022 36(7) 2746-2766. DOI: 10.1002/ptr.7475 (Impact Factor 6.388)
